Journal article
Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain
S Genoud, BR Roberts, AP Gunn, GM Halliday, SJG Lewis, HJ Ball, DJ Hare, KL Double
Metallomics | Published : 2017
DOI: 10.1039/c7mt00244k
Abstract
Elevated iron and decreased copper levels are cardinal features of the degenerating substantia nigra pars compacta in the Parkinson's disease brain. Both of these redox-active metals, and fellow transition metals manganese and zinc, are found at high concentrations within the midbrain and participate in a range of unique biological reactions. We examined the total metal content and cellular compartmentalisation of manganese, iron, copper and zinc in the degenerating substantia nigra, disease-affected but non-degenerating fusiform gyrus, and unaffected occipital cortex in the post mortem Parkinson's disease brain compared with age-matched controls. An expected increase in iron and a decrease ..
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Awarded by National Institutes of Health
Funding Acknowledgements
We acknowledge funding from the Victorian Government's Operational Infrastructure Support Program, Parkinson's NSW and the University of Sydney (Biomedical Science, BRIG). DJH is supported by a National Health and Medical Research Council Industry Career Development Fellowship (1122981) in partnership with Agilent Technologies, GMH is the recipient of a National Health and Medical Research Council (Australia) Senior Principal Research Fellowship (1079679). We wish to thank the New South Wales and Sydney Brain Banks, the donors and their families. Tissues were received from the New South Wales Tissue Resource Centre at the University of Sydney supported by the National Health and Medical Research Council of Australia, Schizophrenia Research Institute and the National Institute of Alcohol Abuse and Alcoholism (NIH (NIAAA) R24AA012725) and from the Sydney Brain Bank which is supported by Neuroscience Research Australia, the University of New South Wales and the National Health and Medical Research Council of Australia.